Medeama take on Great Olympics in the MTN FA Cup Round of 16 with an eye on a quarter-final berth.
The Mauve and Yellows host the Wonder Club on the back of their comeback 2-1 win over Elmina Sharks in the Ghana Premier League.
Medeama see the FA Cup as the only silverware achievable after missing out on the Premier League crown.
The Tarkwa-based side will hope to continue their impressive run in the competition after overcoming third-tier Sekondi Eleven Wise and Premier League rivals Karela United.
Those two feats were chalked in an away matches and will be playing at home for the first time.
They host a Great Olympics side which has been impressive this season.
The Dade Boys accounted for high-flying second-tier side Heart of Lions in Kpando to advance to the Round of 16.
However, they lost ground in their push for a top-four finish after losing 1-0 at home to Techiman Eleven Wonders in the Premier League.
The battle lines are drawn for the two teams who are seeking to advance to the semi-finals of the competition.