Atalanta scored twice in four minutes to deliver a surprise victory over Liverpool and blow qualification from Champions League Group D wide open.
A much-changed Reds side lacked fluidity and failed to have a shot on target at Anfield on Wednesday.
Josip Ilicic and Robin Gosens struck for the Serie A side midway through the second half.
Mohamed Salah, returning to the side, had fired over with the Reds’ best chance in the first half.
The Italian outfit looked more likely to break the deadlock and did so when Ilicic poked beyond Alisson from Alejandro Gomez’s teasing cross.
The visitors doubled their lead four minutes later when an unmarked Gosens volleyed in from Hans Hateboer’s nod down.
Liverpool manager Jurgen Klopp immediately made four substitutions in a bid to get something from the game, but the changes could not prevent the Reds suffering their first home defeat inside 90 minutes since September 2018.
Klopp’s side still remain top of the group and need one win from their final two games – at home to Ajax and away to Midtjylland – to qualify.
The game originally scheduled for Saturday; November 14, 2020 was postponed because the Hearts of Oak camp had been affected by several Covid-19 infections for more than two weeks.
The two former League Champions will now battle each other at the Nana Agyemang Badu I park at Dormaa Ahenkro at 3pm.
The two teams have played one game each in the ongoing 2020/21 season. Aduana stars gave away a 1-0 lead to draw 1-1 with King Faisal on Sunday, while Hearts of Oak settled for a point against AshantiGold in a four-goal thriller on Tuesday, November 24, 2020 at the Accra sports stadium.